Fate has chosen Trey Decarr to become Death, the Fourth Horseman of the Apocalypse. Disgusted by his new role in the coming end, Decarr decides to resist rather than serve, making himself an enemy of Hell and an unpredictable nuisance for Heaven. Decarr finds himself in a losing battle against both angels and demons while he scours the globe hunting the other Horsemen in a desperate attempt to stave off Armageddon.

Meanwhile, a secret order of the church called the Gatekeepers is tasked with killing Decarr, likening him to a rabid dog that needs to be put down. Leading the team that hunts Decarr is young April Frausini. Her orders are simple: kill Death. But April is conflicted, sensing purpose in Decarr's wild actions, and believes he could become a valuable ally in the fight to save the world from annihilation...